SYNE1 and GPX2

		SYNE1	GPX2
Description		spectrin repeat containing nuclear envelope protein 1	glutathione peroxidase 2
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GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	Cytoplasm Cytosol
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Peroxidase Activity Glutathione Peroxidase Activity Electron Transfer Activity
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane	Response To Oxidative Stress Electron Transport Chain Cellular Oxidant Detoxification
Pathways		Meiotic synapsis	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes
Drugs			Glutathione Glutathione Glutathione disulfide
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 28115744 21926972 31043756 28072414 20351715 21738484) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 31249589 30194396 31649266)
Interacting Genes		32 interacting genes: ACTC1 AKAP12 APC BDKRB2 CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 ECPAS EMD GPX2 IL22RA2 IYD LATS1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 NUP43 RAET1E RAET1L SH3BP5 TNIK TP53RK ULBP1 ULBP2 USP21 ZC3H12D	4 interacting genes: MYC PSMB2 SYNE1 TP53
Entrez ID		23345	2877
HPRD ID		09762	11818
Ensembl ID		ENSG00000131018	ENSG00000176153
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	P18283
PDB IDs		4DXR 6R15 6XF2	2HE3
Enriched GO Terms of Interacting Partners?
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