SYNM and PCSK6

		SYNM	PCSK6
Description		synemin	proprotein convertase subtilisin/kexin type 6
Image			No pdb structure
GO Annotations	Cellular Component	Intermediate Filament Adherens Junction Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding
	Biological Process	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity
Pathways			Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		7 interacting genes: DES DTNA ERBB2 ERBB3 ERBB4 PCSK6 SELENOS	12 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PCSK5 PMCH RCN3 SNRPA1 SYNM ZNF441
Entrez ID		23336	5046
HPRD ID		07305	01329
Ensembl ID		ENSG00000182253	ENSG00000140479
Uniprot IDs		A0A075B7B1 O15061	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs		6EWO
Enriched GO Terms of Interacting Partners?
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