TSPYL4 and CDK5RAP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TSPYL4	CDK5RAP3
Description		TSPY like 4	CDK5 regulatory subunit associated protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Nucleosome Assembly	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Liver Development Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Brain Development Cell Population Proliferation Regulation Of Phosphatase Activity Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Definitive Erythrocyte Differentiation Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Fast beta electroencephalogram ( 28040410) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Metabolite levels ( 23823483) Refractive error ( 32231278)	Adult body size ( 32376654) Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		14 interacting genes: CCDC85B CDK5RAP3 CELSR3 CEP57 GOLGA6L9 MAGEA4 NAP1L3 NINL PNMA1 TFIP11 TH TRIM38 ZNF655 ZRANB1	13 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4 UFL1
Entrez ID		23270	80279
HPRD ID		18236	12190
Ensembl ID		ENSG00000187189	ENSG00000108465
Uniprot IDs		Q9UJ04	Q96JB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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