CDK5RAP3 and SRPRB

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		CDK5RAP3	SRPRB
Description		CDK5 regulatory subunit associated protein 3	SRP receptor subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Cytoplasm Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding	GTP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Liver Development Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Brain Development Cell Population Proliferation Regulation Of Phosphatase Activity Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Definitive Erythrocyte Differentiation Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)	Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 29875488) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Nicotine dependence symptom count ( 25555482) Red blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4 UFL1	3 interacting genes: CDK5RAP3 RCHY1 UBC
Entrez ID		80279	58477
HPRD ID		12190	18105
Ensembl ID		ENSG00000108465	ENSG00000144867
Uniprot IDs		Q96JB5	Q549N5 Q9Y5M8
PDB IDs
Enriched GO Terms of Interacting Partners?
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