SYNE2 and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 12118075)
127

Data Source:
HPRD (in vivo)

		SYNE2	ACTC1
Description		spectrin repeat containing nuclear envelope protein 2	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Microfilament Motor Activity ATP Binding Myosin Binding
	Biological Process	Nuclear Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways		Meiotic synapsis	Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)	Axial length ( 24144296) Refractive error ( 32231278 20835239)
Interacting Genes		14 interacting genes: ABI1 ACTC1 BRAP CALM1 ESR2 GLE1 MAPK3 MAPK8IP2 MEOX2 MTNR1B NR2C1 PML SASH1 UBC	42 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		23224	70
HPRD ID		09763	00015
Ensembl ID		ENSG00000054654	ENSG00000159251
Uniprot IDs		Q6MZP0 Q8WXH0	B3KPP5 P68032
PDB IDs		4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?
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