FLT3 and PNPLA3

		FLT3	PNPLA3
Description		fms related receptor tyrosine kinase 3	patatin like phospholipase domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Receptor Complex	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Glucocorticoid Receptor Binding Protein Self-association Protein-containing Complex Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity Lipoprotein Lipase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Acylglycerol O-acyltransferase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Animal Organ Regeneration Positive Regulation Of Kinase Activity Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	Long-chain Fatty Acid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Response To Sucrose Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Insulin Stimulus Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling White Fat Cell Differentiation Lipid Homeostasis Cellular Response To 3,3',5-triiodo-L-thyronine
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants	Acyl chain remodeling of DAG and TAG
Drugs		Sorafenib Sunitinib XL999 Tandutinib ABT-869 Lestaurtinib Midostaurin Ponatinib Nintedanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 32888494 27863252) White blood cell count (monocyte) ( 28158719)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 30718733 31219225 33547301 34315874 33339817) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 31219225 33547301 34315874 29403010 33339817) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Gout ( 33832965) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 21909109) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Nonalcoholic fatty liver disease ( 32298765 21423719 24531328 22719876 29271184 29385134 31311600) Nonalcoholic steatohepatitis ( 32298765) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Percent liver fat ( 34128465) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Serum uric acid levels ( 30993211) Total cholesterol levels ( 33339817 31217584 30275531) Total triglycerides levels ( 26690388) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)
Interacting Genes		25 interacting genes: CBL CBLB CDK8 ERBB2 FIZ1 FLT1 FLT3LG FMO1 GPR12 GRB2 IKBKG INPP5D NCK1 NFIB PNPLA3 PTPN11 PTPN12 PTPN6 SH3BP2 SHC1 SLA SNRPA1 SOCS1 SRC UBE2L6	4 interacting genes: AKT2 FLT3 LINC00839 SNX27
Entrez ID		2322	80339
HPRD ID		00635	12430
Ensembl ID		ENSG00000122025	ENSG00000100344
Uniprot IDs		P36888	Q9NST1
PDB IDs		1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR
Enriched GO Terms of Interacting Partners?
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