FLT3 and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 7505204)
88

Data Source:
HPRD (in vivo)

		FLT3	FLT3LG
Description		fms related receptor tyrosine kinase 3	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Receptor Complex	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Glucocorticoid Receptor Binding Protein Self-association Protein-containing Complex Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Animal Organ Regeneration Positive Regulation Of Kinase Activity Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	Signal Transduction Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis
Pathways		PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		Sorafenib Sunitinib XL999 Tandutinib ABT-869 Lestaurtinib Midostaurin Ponatinib Nintedanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 32888494 27863252) White blood cell count (monocyte) ( 28158719)	Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		25 interacting genes: CBL CBLB CDK8 ERBB2 FIZ1 FLT1 FLT3LG FMO1 GPR12 GRB2 IKBKG INPP5D NCK1 NFIB PNPLA3 PTPN11 PTPN12 PTPN6 SH3BP2 SHC1 SLA SNRPA1 SOCS1 SRC UBE2L6	4 interacting genes: FLT3 KITLG KRTAP5-9 PFN2
Entrez ID		2322	2323
HPRD ID		00635	02477
Ensembl ID		ENSG00000122025	ENSG00000090554
Uniprot IDs		P36888	B7ZLY4 M0QYM9 P49771
PDB IDs		1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?