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FGF10 and SREK1IP1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
FGF10
SREK1IP1
Description
fibroblast growth factor 10
SREK1 interacting protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Plasma Membrane
Cell Surface
Collagen-containing Extracellular Matrix
Molecular Function
Fibroblast Growth Factor Receptor Binding
Type 2 Fibroblast Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemoattractant Activity
Nucleic Acid Binding
Protein Binding
Zinc Ion Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Angiogenesis
Metanephros Development
Organ Induction
Mesonephros Development
Positive Regulation Of Protein Phosphorylation
Blood Vessel Remodeling
Metanephros Morphogenesis
Determination Of Left/right Symmetry
Salivary Gland Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Smoothened Signaling Pathway
Embryonic Pattern Specification
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Keratinocyte Proliferation
Pituitary Gland Development
Cell Differentiation
Regulation Of Cell Migration
Embryonic Genitalia Morphogenesis
Thyroid Gland Development
Otic Vesicle Formation
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pancreas Development
Hair Follicle Morphogenesis
Embryonic Camera-type Eye Development
Actin Cytoskeleton Reorganization
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of ATPase Activity
Lacrimal Gland Development
Regulation Of Activin Receptor Signaling Pathway
Protein Localization To Cell Surface
Somatic Stem Cell Population Maintenance
Wound Healing
Tissue Regeneration
Odontogenesis Of Dentin-containing Tooth
Muscle Cell Fate Commitment
Positive Regulation Of MAPK Cascade
Negative Regulation Of Cell Differentiation
Positive Regulation Of DNA Repair
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Ras Protein Signal Transduction
Regulation Of Saliva Secretion
Positive Regulation Of Fibroblast Proliferation
Spleen Development
Thymus Development
Embryonic Digestive Tract Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Female Genitalia Morphogenesis
Male Genitalia Morphogenesis
Positive Regulation Of Lymphocyte Proliferation
Epithelial Cell Proliferation
Urothelial Cell Proliferation
Positive Regulation Of Urothelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
White Fat Cell Differentiation
Positive Chemotaxis
Induction Of Positive Chemotaxis
Smooth Muscle Cell Differentiation
Positive Regulation Of Keratinocyte Migration
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Limb Development
Limb Bud Formation
Lung Epithelium Development
Lung Saccule Development
Bronchiole Morphogenesis
Bud Outgrowth Involved In Lung Branching
Bud Elongation Involved In Lung Branching
Mesenchymal-epithelial Cell Signaling Involved In Lung Development
Type II Pneumocyte Differentiation
Prostatic Bud Formation
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification
Mammary Gland Bud Formation
Submandibular Salivary Gland Formation
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Branch Elongation Involved In Salivary Gland Morphogenesis
Semicircular Canal Fusion
Mesenchymal Cell Differentiation Involved In Lung Development
Secretion By Lung Epithelial Cell Involved In Lung Growth
Lung Proximal/distal Axis Specification
Tear Secretion
Positive Regulation Of White Fat Cell Proliferation
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Harderian Gland Development
Positive Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
MRNA Processing
RNA Splicing
Pathways
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Regulation of gene expression in early pancreatic precursor cells
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Signaling by FGFR2 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS
Alzheimer disease and age of onset (
26830138
)
Basal cell carcinoma (
31174203
)
Breast cancer (
29059683
31757997
)
Dentures (
31235808
)
Estimated glomerular filtration rate (
31152163
)
FEV1 (
30804560
)
High altitude adaptation (
28373541
)
Keratinocyte cancer (MTAG) (
31174203
)
Lung function (FVC) (
30804560
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Number of decayed, missing and filled tooth surfaces or use of dentures (
31235808
)
Parkinson's disease (
26227905
)
Prostate cancer (
21743467
)
Refractive error (
32231278
)
General cognitive ability (
29844566
)
Interacting Genes
6 interacting genes:
FBXO7
FGFR1
FGFR2
POMC
SREK1IP1
THAP1
28 interacting genes:
AGPAT3
C4orf45
CCNL1
CT45A1
DDIT4L
ELOA2
FGF10
GTF2H4
H2BC15
HPRT1
HSD17B14
LYAR
MACROH2A1
NKAPD1
NKAPL
NME1
PPCDC
PRPF40A
PRR13
RBM39
RNF151
RP9
RP9P
RPL9
SDCBP
SDCBP2
STAC3
THAP1
Entrez ID
2255
285672
HPRD ID
03665
08210
Ensembl ID
ENSG00000070193
ENSG00000153006
Uniprot IDs
O15520
Q8N9Q2
PDB IDs
1NUN
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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