FGF4 and FGFR4

Number of citations of the paper that reports this interaction (PubMedID 8663044)
422

Data Source:
HPRD (in vitro)

		FGF4	FGFR4
Description		fibroblast growth factor 4	fibroblast growth factor receptor 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding
	Biological Process	Cartilage Condensation Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Mesenchymal Cell Proliferation Positive Regulation Of Gene Expression Stem Cell Population Maintenance Cell Differentiation Regulation Of Cell Migration Embryonic Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Leukemia Inhibitory Factor Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Positive Regulation Of Kinase Activity Glucose Homeostasis Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Protein Autophosphorylation Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Positive Regulation Of DNA Biosynthetic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 mutant receptor activation FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling Signaling by FGFR4 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Pentosan polysulfate Heparin TP-508	Heparin Ponatinib Lenvatinib Erdafitinib Pemigatinib
Diseases
GWAS		Birth weight ( 31043758) Breast cancer ( 20453838) Craniofacial microsomia ( 26853712) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Urate levels in overweight individuals ( 25811787)	Activated partial thromboplastin time ( 22703881) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 28552196 25282103 31562340) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hip shape (DXA scan) ( 30320955) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Type 2 diabetes ( 32499647 30718926) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 NRP1	85 interacting genes: ABCB5 AKT1 ANGPTL4 ARAF ARNT BECN1 BLID CASC3 CBLC CCND2 CCNE1 CD44 CDH2 CDK4 CDK6 CDKN2A CDKN2B CDKN2C DIRAS3 EPHA2 EPHA4 EPSTI1 ERBB2 ERRFI1 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FZR1 GLCE GLIS2 GRM1 HGF HIF1A IFT80 IGF1R KDELR2 LATS2 LRATD2 MAP2K5 MAP2K6 MAP3K5 MAPK14 MDM4 MET MSH2 MTA3 MYC NF2 NSD3 OSGIN1 PDGFRA PDLIM2 PLCG1 PPP3CA PSMC3IP PTPN11 PTPN12 PTPN6 PTPRR RAF1 RASL10B RASSF1 RNF20 ROS1 SCGB3A1 STAT1 STAT3 STC2 STK11 TEAD2 TERT THRSP TP53 TSC1 TTYH2 WIF1
Entrez ID		2249	2264
HPRD ID		01294	00625
Ensembl ID		ENSG00000075388	ENSG00000160867
Uniprot IDs		P08620	B4DVP5 J3KPQ0 P22455
PDB IDs		1IJT	1QCT 4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG 5NUD 5NWZ 5XFF 5XFJ 6IUO 6IUP 6J6Y 6JPE 6JPJ 6NVG 6NVH 6NVI 6NVJ 6NVK 6V9C 6YI8
Enriched GO Terms of Interacting Partners?
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