Description |
FES proto-oncogene, tyrosine kinase |
BCR activator of RhoGEF and GTPase |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
- Autism spectrum disorder or schizophrenia ( 28540026)
- Birth weight ( 31043758 27680694)
- Blood pressure ( 21909110)
- Brain morphology (MOSTest) ( 32665545)
- Caffeine consumption from coffee ( 33287642)
- Coffee consumption ( 31046077)
- Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668)
- Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
- Daytime sleep phenotypes ( 27126917)
- Diastolic blood pressure ( 27841878 21909115 28739976 27618452)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
- Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Hypertension ( 31879980 21909115)
- Ischemic stroke ( 29531354)
- Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
- Medication use (agents acting on the renin-angiotensin system) ( 31015401)
- Medication use (beta blocking agents) ( 31015401)
- Medication use (calcium channel blockers) ( 31015401)
- Medication use (diuretics) ( 31015401)
- Myocardial infarction ( 33532862 26343387)
- Number of sexual partners ( 30643258)
- Offspring birth weight ( 31043758)
- Parental lifespan ( 30642433)
- Pulse pressure ( 27841878 30578418)
- Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
- Schizophrenia ( 25056061 29483656 30285260)
- Stroke ( 29531354)
- Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418)
- Systolic blood pressure (cigarette smoking interaction) ( 29455858)
- Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
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Interacting Genes |
50 interacting genes:
ALDH1B1
APP
AR
BCAR1
BCR
BLM
CBX5
CSF2RB
DOK1
DPYSL5
EGFR
ERBB2
ERBB3
ERBB4
FKBP4
FKBP5
FURIN
GAB1
HSH2D
HSPA4
IL4R
IRS1
IRS2
JAK1
JAK2
JAK3
KIT
MAN2A2
MDFI
MET
NEDD4
NLGN4X
PDE4DIP
PEX11A
PIK3R1
PLXNA1
POT1
PPID
PTGES3
RASA1
RASA3
SMURF1
STARD5
STAT3
TERF1
TRIM28
VANGL1
ZNF117
ZNF746
ZNF775
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45 interacting genes:
ABL1
ABL2
AFDN
APBA3
BLK
CBL
CDC42
CRK
CRKL
DLG1
DOK1
ERCC3
FES
GRB10
GRB2
HCK
HNF1A
IGSF21
IRS1
JAK2
LNX1
MAP4K5
PLCG1
PTPN1
PTPN11
PTPN6
RAC1
RAD51
RASA1
RHOA
SFN
SHC1
SRC
STUB1
TP53
TSG101
UBC
UNC119
VAV1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
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Entrez ID |
2242 |
613 |
HPRD ID |
01814 |
01044 |
Ensembl ID |
ENSG00000182511
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ENSG00000186716
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Uniprot IDs |
A0A024RC92
P07332
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P11274
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PDB IDs |
1WQU
2DCR
3BKB
3CBL
3CD3
4DYL
4E93
6JMF
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1K1F
2AIN
5N6R
5N7E
5OC7
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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