FECH and ABCB7

Number of citations of the paper that reports this interaction (PubMedID 12480705)
26

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		FECH	ABCB7
Description		ferrochelatase	ATP binding cassette subfamily B member 7
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Ferrochelatase Activity Protein Binding Ferrous Iron Binding Protein Homodimerization Activity 2 Iron, 2 Sulfur Cluster Binding	Protein Binding ATP Binding Heme Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ABC-type Iron-sulfur Cluster Transporter Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Heme Biosynthetic Process Response To Xenobiotic Stimulus Response To Light Stimulus Response To Lead Ion Response To Insecticide Response To Ethanol Protoporphyrinogen IX Metabolic Process Response To Arsenic-containing Substance Response To Methylmercury Response To Platinum Ion Cellular Response To Dexamethasone Stimulus	Cellular Iron Ion Homeostasis Heme Transport Iron-sulfur Cluster Assembly Iron Ion Transmembrane Transport Iron Ion Homeostasis Transmembrane Transport Positive Regulation Of Heme Biosynthetic Process Iron-sulfur Cluster Export From The Mitochondrion Positive Regulation Of Iron-sulfur Cluster Assembly Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Heme biosynthesis	Mitochondrial ABC transporters Cytosolic iron-sulfur cluster assembly
Drugs		Cholic Acid Cholic Acid
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Migraine ( 27182965) Red cell distribution width ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: ABCB7 ATM DCC	4 interacting genes: APP FECH RAP1GDS1 UBC
Entrez ID		2235	22
HPRD ID		01509	02137
Ensembl ID		ENSG00000066926	ENSG00000131269
Uniprot IDs		A0A499FJN5 P22830 Q7KZA3	A0A087WW65 A0A0S2Z2Z3 O75027
PDB IDs		1HRK 2HRC 2HRE 2PNJ 2PO5 2PO7 2QD1 2QD2 2QD3 2QD4 2QD5 3AQI 3HCN 3HCO 3HCP 3HCR 3W1W 4F4D 4KLA 4KLC 4KLR 4KMM 4MK4
Enriched GO Terms of Interacting Partners?
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