ABCB7 and FECH

Number of citations of the paper that reports this interaction (PubMedID 12480705)
26

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		ABCB7	FECH
Description		ATP binding cassette subfamily B member 7	ferrochelatase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Protein Binding ATP Binding Heme Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ABC-type Iron-sulfur Cluster Transporter Activity	Ferrochelatase Activity Protein Binding Ferrous Iron Binding Protein Homodimerization Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Cellular Iron Ion Homeostasis Heme Transport Iron-sulfur Cluster Assembly Iron Ion Transmembrane Transport Iron Ion Homeostasis Transmembrane Transport Positive Regulation Of Heme Biosynthetic Process Iron-sulfur Cluster Export From The Mitochondrion Positive Regulation Of Iron-sulfur Cluster Assembly Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Generation Of Precursor Metabolites And Energy Heme Biosynthetic Process Response To Xenobiotic Stimulus Response To Light Stimulus Response To Lead Ion Response To Insecticide Response To Ethanol Protoporphyrinogen IX Metabolic Process Response To Arsenic-containing Substance Response To Methylmercury Response To Platinum Ion Cellular Response To Dexamethasone Stimulus
Pathways		Mitochondrial ABC transporters Cytosolic iron-sulfur cluster assembly	Heme biosynthesis
Drugs			Cholic Acid Cholic Acid
Diseases
GWAS		Metabolite levels ( 23823483)	Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Migraine ( 27182965) Red cell distribution width ( 32888494)
Interacting Genes		4 interacting genes: APP FECH RAP1GDS1 UBC	3 interacting genes: ABCB7 ATM DCC
Entrez ID		22	2235
HPRD ID		02137	01509
Ensembl ID		ENSG00000131269	ENSG00000066926
Uniprot IDs		A0A087WW65 A0A0S2Z2Z3 O75027	A0A499FJN5 P22830 Q7KZA3
PDB IDs			1HRK 2HRC 2HRE 2PNJ 2PO5 2PO7 2QD1 2QD2 2QD3 2QD4 2QD5 3AQI 3HCN 3HCO 3HCP 3HCR 3W1W 4F4D 4KLA 4KLC 4KLR 4KMM 4MK4
Enriched GO Terms of Interacting Partners?
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