FCGR2B and INPPL1

Number of citations of the paper that reports this interaction (PubMedID 10789675)
12

Data Source:
HPRD (in vivo, in vitro)

		FCGR2B	INPPL1
Description		Fc fragment of IgG receptor IIb	inositol polyphosphate phosphatase like 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Dendritic Spine Cell Body	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Protein Binding Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding	Actin Binding Protein Binding SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding
	Biological Process	Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Cytokine Production Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Regulation Of Signaling Receptor Activity Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Neuron Death Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling
Drugs		Etanercept Human immunoglobulin G Abciximab Tositumomab Alemtuzumab Antithymocyte immunoglobulin (rabbit) Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758 27680694) Blood protein levels ( 30072576 29875488 28240269) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) IgG levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Lipid metabolism phenotypes ( 22286219) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Rheumatoid arthritis ( 30423114) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		22 interacting genes: AP3B1 APCS BLK CRP ERG28 FCER1G FCGR2A GAB1 GRB2 HSPA6 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 MGST3 MRTFB PRKCA PTPN11 PTPN6 ZBTB18	24 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R DRD2 EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 HYOU1 KMT2A MET SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		2213	3636
HPRD ID		06849	02900
Ensembl ID		ENSG00000072694	ENSG00000165458
Uniprot IDs		P31994	O15357
PDB IDs		2FCB 3WJJ 5OCC	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR
Enriched GO Terms of Interacting Partners?
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