FCGR1A and ASGR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FCGR1A	ASGR1
Description		Fc fragment of IgG receptor Ia	asialoglycoprotein receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Positive Regulation Of Protein Tyrosine Kinase Activity	Receptor-mediated Endocytosis Cellular Response To Extracellular Stimulus
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis	Asparagine N-linked glycosylation
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 33547301 31666285 29403010 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B	44 interacting genes: AHNAK2 AMIGO1 APH1A APP ASGR2 ATP1B4 BLCAP CERS2 CLDN7 CLEC4G CPLX4 CREB3L1 CYB5R3 DHFR ERGIC3 FAM209A FCGR1A FNDC9 GPX8 HIBADH HIVEP1 HSP90AA1 HSP90B1 IGFBP5 KIR2DL3 LAMTOR5 LEUTX LMNA MCEMP1 NEMP1 NLK PDZK1IP1 PLS3 RBBP6 RNF19B SAR1A SLC10A1 SLC35C2 SPAG4 SUSD3 TG TMX2 VKORC1 VSIR
Entrez ID		2209	432
HPRD ID		00904	00151
Ensembl ID		ENSG00000150337	ENSG00000141505
Uniprot IDs		P12314	P07306 Q6FGQ5
PDB IDs		3RJD 4W4O 4X4M 4ZNE	1DV8 5JPV 5JQ1 6YAU
Enriched GO Terms of Interacting Partners?
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