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PTK2B and CBL
Number of citations of the paper that reports this interaction (PubMedID
11149930
)
118
Data Source:
HPRD
(in vivo)
PTK2B
CBL
Description
protein tyrosine kinase 2 beta
Cbl proto-oncogene
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Focal Adhesion
Cell Cortex
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Lamellipodium
Dendrite
Growth Cone
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuronal Cell Body
Dendritic Spine
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Apical Dendrite
Glutamatergic Synapse
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Flotillin Complex
Growth Cone
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Calmodulin-dependent Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
NMDA Glutamate Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Ubiquitin Protein Ligase Binding
3-phosphoinositide-dependent Protein Kinase Binding
Protein-containing Complex Binding
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Biological Process
MAPK Cascade
Oocyte Maturation
Response To Hypoxia
Positive Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Adaptive Immune Response
Marginal Zone B Cell Differentiation
Protein Phosphorylation
Apoptotic Process
Cellular Defense Response
Response To Osmotic Stress
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Hormone
Response To Glucose
Response To Lithium Ion
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Muscle Cell Apoptotic Process
Regulation Of CGMP-mediated Signaling
Regulation Of Macrophage Chemotaxis
Positive Regulation Of Neuron Projection Development
Glial Cell Proliferation
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Actin Filament Polymerization
Neuron Projection Development
Regulation Of Inositol Trisphosphate Biosynthetic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Response To Immobilization Stress
Peptidyl-tyrosine Autophosphorylation
Response To Cocaine
Response To Hydrogen Peroxide
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Stress Fiber Assembly
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Bone Resorption
Response To Ethanol
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Synaptic Plasticity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Calcium-mediated Signaling
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Response To CAMP
Response To Calcium Ion
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Protein-containing Complex Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Fluid Shear Stress
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Establishment Of Cell Polarity
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of NMDA Receptor Activity
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of B Cell Chemotaxis
Positive Regulation Of DNA Biosynthetic Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Male Gonad Development
Response To Gamma Radiation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Entry Of Bacterium Into Host Cell
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Antibiotic
Positive Regulation Of Receptor-mediated Endocytosis
Neuron Death
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Oxygen-glucose Deprivation
Negative Regulation Of Neuron Death
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
RHOU GTPase cycle
Interleukin-2 signaling
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Drugs
Leflunomide
Genistein
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Baricitinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
30617256
24162737
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bone mineral content (
31790847
)
Bone mineral density (
31790847
)
Crohn's disease (
26192919
)
Dental caries (
23259602
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Family history of Alzheimer's disease (
30617256
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
32888494
)
Schizophrenia (
29483656
)
Takayasu arteritis (
33308445
25604533
30498034
)
White blood cell count (
32888494
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
22139419
29403010
33545615
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Triglyceride levels (
33339817
)
Interacting Genes
69 interacting genes:
ARHGAP21
ARHGAP5
ASAP1
ASAP2
BCAR1
CBL
CCR5
CRK
DLG3
DLG4
DLGAP3
EFS
EGFR
ERBB2
ERBB3
EWSR1
FGFR2
FGFR3
FLT1
FYN
GNA13
GRB2
GRIN2A
GSN
IL7R
ITGB2
ITGB3
JAK1
JAK2
JAK3
KCNA2
LCK
LPXN
LYN
MAP3K4
MAPT
MATK
MCAM
MYH2
NEDD9
NPHP1
PDCD6IP
PDPK1
PIK3R1
PITPNM1
PITPNM2
PITPNM3
PRKCD
PTK2
PTPN11
PTPN12
PTPN6
PXN
RASA1
RB1CC1
SH2D3C
SHC1
SKAP2
SLC2A1
SNCA
SORBS2
SRC
STAP1
STAT3
SYK
TGFB1I1
TLN1
VAV1
ZAP70
130 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
CXCR5
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
ETS1
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PRKCA
PRKCQ
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TNS4
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
Entrez ID
2185
867
HPRD ID
03131
01320
Ensembl ID
ENSG00000120899
ENSG00000110395
Uniprot IDs
Q14289
P22681
PDB IDs
2FO6
2LK4
3CC6
3ET7
3FZO
3FZP
3FZR
3FZS
3FZT
3GM1
3GM2
3GM3
3H3C
3U3F
4EKU
4H1J
4H1M
4R32
4XEF
4XEK
4XEV
5TO8
5TOB
6LF3
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
6XAR
Enriched GO Terms of Interacting Partners
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