ALDH1A1 and NUPR1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ALDH1A1	NUPR1
Description		aldehyde dehydrogenase 1 family member A1	nuclear protein 1, transcriptional regulator
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Axon Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	Retinal Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity GTPase Activator Activity Androgen Binding Protein Binding Benzaldehyde Dehydrogenase (NAD+) Activity Aminobutyraldehyde Dehydrogenase Activity NAD Binding 3-deoxyglucosone Dehydrogenase Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Acetyltransferase Activator Activity
	Biological Process	Retinoid Metabolic Process Cellular Aldehyde Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Fructosamine Catabolic Process Maintenance Of Lens Transparency Retinol Metabolic Process Regulation Of Catalytic Activity Cellular Detoxification Of Aldehyde Negative Regulation Of Cold-induced Thermogenesis	Acute Inflammatory Response Protein Acetylation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Protein Modification Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Negative Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Assembly Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Autophagosome Assembly Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Female Gonad Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		RA biosynthesis pathway Fructose catabolism Ethanol oxidation
Drugs		NADH Vitamin A Tretinoin 1,4-Dithiothreitol
Diseases
GWAS		Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Sensorimotor dexterity ( 31596458)	Alcohol consumption (drinks per week) ( 30679032) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Offspring birth weight ( 31043758) Refractive error ( 32231278) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		5 interacting genes: ALDH2 BRCA1 NUPR1 POT1 PTPRF	17 interacting genes: ABCG8 ALDH1A1 EP300 KNSTRN MAPRE1 MPHOSPH6 MSL1 NPY5R PAXIP1 PTMA RANBP1 RPL41 SEC11A SET STX18 SYNCRIP TUBA4A
Entrez ID		216	26471
HPRD ID		00001	17814
Ensembl ID		ENSG00000165092	ENSG00000176046
Uniprot IDs		P00352 V9HW83	A0A024QZC4 O60356
PDB IDs		4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI 6DUM 7JWS 7JWT 7JWU 7JWV 7JWW
Enriched GO Terms of Interacting Partners?
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