EXT2 and GALNT5

Number of citations of the paper that reports this interaction (PubMedID 10545594)
17

Data Source:
HPRD (two hybrid, in vitro)

		EXT2	GALNT5
Description		exostosin glycosyltransferase 2	polypeptide N-acetylgalactosaminyltransferase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome	Golgi Membrane Cellular_component Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Ossification Mesoderm Formation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Signal Transduction Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Heparin Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis	Glycosaminoglycan Biosynthetic Process O-glycan Processing
Pathways		HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS	O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)	Schizophrenia x sex interaction ( 34099189)
Interacting Genes		10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1	2 interacting genes: EXT2 GPD2
Entrez ID		2132	11227
HPRD ID		00599	09970
Ensembl ID		ENSG00000151348	ENSG00000136542
Uniprot IDs		D3DR24 Q93063	Q7Z7M9
PDB IDs
Enriched GO Terms of Interacting Partners?
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