GALNT5 and EXT2

Number of citations of the paper that reports this interaction (PubMedID 10545594)
17

Data Source:
HPRD (two hybrid, in vitro)

		GALNT5	EXT2
Description		polypeptide N-acetylgalactosaminyltransferase 5	exostosin glycosyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cellular_component Golgi Apparatus Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Glycosaminoglycan Biosynthetic Process O-glycan Processing	Ossification Mesoderm Formation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Signal Transduction Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Heparin Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis
Pathways		O-linked glycosylation of mucins	HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: EXT2 GPD2	10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1
Entrez ID		11227	2132
HPRD ID		09970	00599
Ensembl ID		ENSG00000136542	ENSG00000151348
Uniprot IDs		Q7Z7M9	D3DR24 Q93063
PDB IDs
Enriched GO Terms of Interacting Partners?
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