C8orf74 and SUV39H2

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		C8orf74	SUV39H2
Description		chromosome 8 open reading frame 74	SUV39H2 histone lysine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) S-adenosyl-L-methionine Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Fish- and plant-related diet ( 32066663) Processed meat consumption ( 32066663) Suicide ( 26079190)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		14 interacting genes: DEFB105A DEFB106A DEFB107A DEFB130A KDM1A PRMT6 PRSS55 SUV39H1 SUV39H2 TDH TRIM54 TRIM55 TRIM63 ZNF655	41 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		203076	79723
HPRD ID		19096	07580
Ensembl ID		ENSG00000171060	ENSG00000152455
Uniprot IDs		Q6P047	Q9H5I1
PDB IDs			2R3A 6P0R
Enriched GO Terms of Interacting Partners?
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