SUV39H2 and KLHDC4

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SUV39H2	KLHDC4
Description		SUV39H2 histone lysine methyltransferase	kelch domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) S-adenosyl-L-methionine Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Hippocampal volume in mild cognitive impairment ( 29274321)
Interacting Genes		41 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57	8 interacting genes: CEP76 KDM1A MFHAS1 SUV39H1 SUV39H2 TERF1 TRIM55 TRIM63
Entrez ID		79723	54758
HPRD ID		07580	11180
Ensembl ID		ENSG00000152455	ENSG00000104731
Uniprot IDs		Q9H5I1	Q8TBB5
PDB IDs		2R3A 6P0R
Enriched GO Terms of Interacting Partners?
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