SERPINB1 and PRTN3

Number of citations of the paper that reports this interaction (PubMedID 12114510)
15

Data Source:
HPRD (in vitro)

		SERPINB1	PRTN3
Description		serpin family B member 1	proteinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Early Endosome Membrane Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Plasma Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Plasma Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Interleukin-1 Beta Production Type B Pancreatic Cell Proliferation	Proteolysis Membrane Protein Ectodomain Proteolysis Phagocytosis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways		Neutrophil degranulation	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs			Elafin
Diseases
GWAS		BMI at 5 years old ( 31575865) Cerebrospinal fluid AB1-42 levels ( 28247064)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		4 interacting genes: CDC42 ELANE PRTN3 XPO1	13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		1992	5657
HPRD ID		00555	01512
Ensembl ID		ENSG00000021355	ENSG00000196415
Uniprot IDs		P30740 V9HWH1	P24158
PDB IDs		4GA7	1FUJ
Enriched GO Terms of Interacting Partners?
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