EIF5 and PUM1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		EIF5	PUM1
Description		eukaryotic translation initiation factor 5	pumilio RNA binding family member 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity	Spermatogenesis Adult Locomotory Behavior Posttranscriptional Regulation Of Gene Expression Posttranscriptional Gene Silencing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of Gene Silencing By MiRNA MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		17 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1	47 interacting genes: ATXN1 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1
Entrez ID		1983	9698
HPRD ID		03417	06230
Ensembl ID		ENSG00000100664	ENSG00000134644
Uniprot IDs		A0A024R6Q1 P55010	Q14671
PDB IDs		2E9H 2G2K 2IU1	1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?
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