EIF5 and EIF4G2

Number of citations of the paper that reports this interaction (PubMedID 11331597)
57

Data Source:
HPRD (in vitro)

		EIF5	EIF4G2
Description		eukaryotic translation initiation factor 5	eukaryotic translation initiation factor 4 gamma 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon
	Molecular Function	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity	Translational Initiation Regulation Of Translational Initiation Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Regulation Of Cell Cycle Positive Regulation Of Dendritic Spine Development
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)	Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1	16 interacting genes: C1QTNF9 CASP3 CREBBP EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 OGT POLE3 RPA2 SKIL SUMO2
Entrez ID		1983	1982
HPRD ID		03417	09084
Ensembl ID		ENSG00000100664	ENSG00000110321
Uniprot IDs		A0A024R6Q1 P55010	P78344 Q2TU89
PDB IDs		2E9H 2G2K 2IU1	3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?
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