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EPHA2 and LATS2
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
52
Data Source:
BioGRID
(fluorescent resonance energy transfer)
EPHA2
LATS2
Description
EPH receptor A2
large tumor suppressor kinase 2
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Lamellipodium
Leading Edge Membrane
Lamellipodium Membrane
Ruffle Membrane
Neuron Projection
Receptor Complex
Tight Junction
Spindle Pole
Nucleus
Cytosol
Centriolar Satellite
Molecular Function
Virus Receptor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Cadherin Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Skeletal System Development
Vasculogenesis
Osteoblast Differentiation
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Lamellipodium Assembly
Notochord Formation
Cell Migration
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Neural Tube Development
Keratinocyte Differentiation
Osteoclast Differentiation
Negative Regulation Of Chemokine Production
Mammary Gland Epithelial Cell Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Kinase Activity
Post-anal Tail Morphogenesis
Protein Kinase B Signaling
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Angiogenesis
CAMP Metabolic Process
Viral Entry Into Host Cell
Bone Remodeling
Ephrin Receptor Signaling Pathway
Axial Mesoderm Formation
Cell Motility
Defense Response To Gram-positive Bacterium
Negative Regulation Of Protein Kinase B Signaling
Notochord Cell Development
Cell Chemotaxis
Branching Involved In Mammary Gland Duct Morphogenesis
Lens Fiber Cell Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Negative Regulation Of Lymphangiogenesis
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Bicellular Tight Junction Assembly
Pericyte Cell Differentiation
G1/S Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by Hippo
Drugs
Dasatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Regorafenib
Fostamatinib
Diseases
GWAS
Alanine aminotransferase levels (
33547301
34315874
33339817
)
Aspartate aminotransferase levels (
33547301
34315874
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Hip circumference adjusted for BMI (
34021172
)
Refractive error (
32231278
)
Interacting Genes
87 interacting genes:
ABCB5
ACP1
AKT1
ANXA1
APP
ARAF
ARNT
AURKA
BECN1
CBL
CBLC
CCND2
CD44
CDC42
CDH5
CDK17
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLDN4
DUSP14
DUSP18
DUSP19
DUSP26
DUSP29
EFNA1
EFNA2
EFNA3
EFNA4
EFNA5
EGFR
ERBB2
FGFR4
FZR1
GATAD1
GIGYF2
GLIS2
GRB2
GRK2
GRM1
HGF
HIF1A
ILKAP
KDELR2
KPNA3
LATS2
LSM7
MAP2K5
MAP2K6
MAPK14
MDM4
MET
MSH2
MYC
NF1
NF2
NFIC
NUDT9
PDGFRA
PIK3R1
PIK3R2
PPM1L
PSME2
PTEN
PTK2
PTPN11
PTPN7
PTPRR
RAF1
RASA1
RASSF1
RBL1
RELA
SHC1
SLA
STK11
STYX
TEAD2
TIAM1
TNFAIP1
TNFRSF8
TP53
TPTE
TPTE2
UBE4A
68 interacting genes:
ABL1
AJUBA
AKT1
ARAF
ARNT
AURKA
AURKB
BECN1
BRAF
CBLC
CCND2
CCNE1
CD44
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CHEK1
CHEK2
CTNNB1
DYRK1A
EPHA2
ERBB2
EZH2
FGFR4
FHL3
FLT1
FZR1
GLIS1
GLIS2
GRAP2
GRM1
HGF
HIF1A
KAT2A
KDELR2
KIF23
MAP2K3
MAP2K5
MAPK14
MDM4
MET
MOB3A
MOB3B
MOB3C
MOB4
MYC
NF2
NFIC
PDGFRA
RAF1
RASSF1
RELA
SMAD2
SNAI1
STK11
STK3
SUZ12
TAFAZZIN
TEAD2
TP53
TSC1
WWTR1
YWHAG
YWHAZ
Entrez ID
1969
26524
HPRD ID
01494
07277
Ensembl ID
ENSG00000142627
ENSG00000150457
Uniprot IDs
A0A024QZA8
P29317
A0A024RDM3
Q9NRM7
PDB IDs
1MQB
2E8N
2K9Y
2KSO
2X10
2X11
3C8X
3CZU
3FL7
3HEI
3HPN
3KKA
3MBW
3MX0
3SKJ
4P2K
4PDO
4TRL
5EK7
5I9U
5I9V
5I9W
5I9X
5I9Y
5I9Z
5IA0
5IA1
5IA2
5IA3
5IA4
5IA5
5NJZ
5NK0
5NK1
5NK2
5NK3
5NK4
5NK5
5NK6
5NK7
5NK8
5NK9
5NKA
5NKB
5NKC
5NKD
5NKE
5NKF
5NKG
5NKH
5NKI
5NZ9
6B9L
6F7M
6F7N
6FNF
6FNG
6FNH
6HES
6HET
6HEU
6HEV
6HEW
6HEX
6HEY
6NJZ
6NK0
6NK1
6NK2
6NKP
6Q7B
6Q7C
6Q7D
6Q7E
6Q7F
6Q7G
6RW2
7B7N
7CZE
7CZF
7KJA
7KJB
7KJC
4ZRI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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