ANO6 and PRICKLE1

		ANO6	PRICKLE1
Description		anoctamin 6	prickle planar cell polarity protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Chloride Channel Complex Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleus Cytosol Nuclear Membrane
	Molecular Function	Calcium Activated Cation Channel Activity Intracellular Calcium Activated Chloride Channel Activity Voltage-gated Ion Channel Activity Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Phospholipid Scramblase Activity Metal Ion Binding Protein Dimerization Activity	Protein Binding Zinc Ion Binding
	Biological Process	Dendritic Cell Chemotaxis Activation Of Blood Coagulation Via Clotting Cascade Cation Transport Chloride Transport Induction By Virus Of Host Cell-cell Fusion Blood Coagulation Plasma Membrane Phospholipid Scrambling Positive Regulation Of Bone Mineralization Bleb Assembly Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Pore Complex Assembly Transmembrane Transport Positive Regulation Of Phagocytosis, Engulfment Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phosphatidylcholine Scrambling Calcium Ion Transmembrane Transport Positive Regulation Of Monocyte Chemotaxis Phosphatidylserine Exposure On Blood Platelet Chloride Transmembrane Transport Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways		Stimuli-sensing channels Neutrophil degranulation	Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Insomnia ( 29520036) Urate levels in obese individuals ( 25811787) Waist circumference adjusted for body mass index ( 28552196)	Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		9 interacting genes: ALG10B ARID2 C12orf40 CPNE8 GXYLT1 LRRK2 MUC19 PRICKLE1 SLC2A13	14 interacting genes: ANO6 ARID2 BYSL CECR2 HIP1R JRK KIF9 LRRK2 PPP3CB PRPF31 SMURF2 TYR UTP14C VIP
Entrez ID		196527	144165
HPRD ID		18746	16341
Ensembl ID		ENSG00000177119	ENSG00000139174
Uniprot IDs		B3KX12 Q4KMQ2	A0A024R0W7 B3KVG3 B3KVG6 Q96MT3
PDB IDs
Enriched GO Terms of Interacting Partners?
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