EGR2 and RIMKLB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		EGR2	RIMKLB
Description		early growth response 2	ribosomal modification protein rimK like family member B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	ATP Binding Ligase Activity, Forming Carbon-nitrogen Bonds Metal Ion Binding N-acetyl-L-aspartate-L-glutamate Ligase Activity Citrate-L-glutamate Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Learning Or Memory Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Response To Insulin Brain Segmentation Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neuronal Synaptic Plasticity Cellular Response To Organic Substance	Cellular Protein Modification Process Glutamine Family Amino Acid Metabolic Process
Pathways		Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	Glutamate and glutamine metabolism
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Daytime nap ( 33568662) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		21 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 KCTD17 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WWP2	1 interacting genes: EGR2
Entrez ID		1959	57494
HPRD ID		00551	13844
Ensembl ID		ENSG00000122877	ENSG00000166532
Uniprot IDs		P11161	Q9ULI2
PDB IDs
Enriched GO Terms of Interacting Partners?
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