EGR2 and NFATC1

Number of citations of the paper that reports this interaction (PubMedID 12560487)
51

Data Source:
BioGRID (pull down)

		EGR2	NFATC1
Description		early growth response 2	nuclear factor of activated T cells 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding FK506 Binding Transcription Factor Binding Mitogen-activated Protein Kinase P38 Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Learning Or Memory Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Response To Insulin Brain Segmentation Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neuronal Synaptic Plasticity Cellular Response To Organic Substance	Cytokine Production Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Wnt Signaling Pathway Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Pseudoephedrine
Diseases
GWAS		Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Daytime nap ( 33568662) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)	Blood urea nitrogen levels ( 31152163 29403010) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 31152163 29124443) Creatinine levels ( 31015462 29124443 29403010) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling hurt ( 29500382) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hyperuricemia ( 29124443) Inflammatory bowel disease ( 26192919) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neonatal white matter microstructure ( 33009551) Neutrophil percentage of white cells ( 32888494) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum creatinine levels ( 29779033) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		21 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 KCTD17 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WWP2	16 interacting genes: EGR1 EGR2 EP300 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA RACK1 SPI1 TUBA1A YWHAQ
Entrez ID		1959	4772
HPRD ID		00551	02729
Ensembl ID		ENSG00000122877	ENSG00000131196
Uniprot IDs		P11161	A8K9C6 B4DER8 F5H4S8 O95644
PDB IDs			1A66 1NFA 5SVE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?