EFNA1 and EPHA6

Number of citations of the paper that reports this interaction (PubMedID 8755474)
231

Data Source:
HPRD (in vitro)

		EFNA1	EPHA6
Description		ephrin A1	EPH receptor A6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Anchored Component Of Plasma Membrane	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Ephrin Receptor Binding	Molecular_function Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Positive Regulation Of Protein Phosphorylation Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Biological_process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Ephrin Receptor Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emotional recognition ( 31596458) Gamma glutamyl transferase levels ( 33339817) Inflammatory bowel disease ( 28067908) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Urinary albumin excretion ( 30220432)	Blood trace element (Cu levels) ( 23720494) Blood trace element (Zn levels) ( 23720494) Longevity ( 26912274) Obesity-related traits ( 23251661) Systolic blood pressure ( 29208002) Weight ( 28552196) White matter hyperintensity volume ( 33293549)
Interacting Genes		15 interacting genes: ADAM10 CD48 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6	2 interacting genes: EFNA1 EFNA4
Entrez ID		1942	285220
HPRD ID		01858	13275
Ensembl ID		ENSG00000169242	ENSG00000080224
Uniprot IDs		P20827	A0A0B4J1T8 B3KS12 Q6UWM0 Q9UF33
PDB IDs		3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?
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