EEF1D and RNF40

Number of citations of the paper that reports this interaction (PubMedID 30649429)
3

Data Source:
BioGRID (enzymatic study)

		EEF1D	RNF40
Description		eukaryotic translation elongation factor 1 delta	ring finger protein 40
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Membrane Extrinsic Component Of Membrane HULC Complex Neuron Projection Axon Terminus
	Molecular Function	DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Syntaxin-1 Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Translational Elongation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Catalytic Activity Cellular Response To Ionizing Radiation	Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Histone H2B Ubiquitination Response To Peptide Hormone Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Histone H2B Ubiquitination
Pathways		Eukaryotic Translation Elongation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Schizophrenia ( 31268507)	Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		44 interacting genes: ABTB1 ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 ERP27 FKBP6 FOS FRA10AC1 GARS1 HEXD HSF1 KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SQSTM1 TERF1 TINF2 TPT1 UBE2A VARS1	27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DISC1 DUSP29 EEF1D GRIN2A ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL RB1 RNF20 SFR1 TRIM51 UBE2A UBE2B UBE2D2 UBE2E1 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		1936	9810
HPRD ID		00560	07411
Ensembl ID		ENSG00000104529	ENSG00000103549
Uniprot IDs		B2RAR6 D3DWK1 P29692	A8K6K1 O75150
PDB IDs		2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?
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