LPAR1 and GNAI3

Number of citations of the paper that reports this interaction (PubMedID 9600933)
60

Data Source:
HPRD (in vitro)

		LPAR1	GNAI3
Description		lysophosphatidic acid receptor 1	G protein subunit alpha i3
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Regulation Of Metabolic Process Neurogenesis Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis	Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal structure ( 23291589) Cortical thickness ( 32963231) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 20881960 25282103 31562340) Monocyte count ( 28193307 29403010 32888494 28031487) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS SLC9A3R2	43 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		1902	2773
HPRD ID		03790	00765
Ensembl ID		ENSG00000198121	ENSG00000065135
Uniprot IDs		Q5VZX0 Q92633	P08754
PDB IDs		4Z34 4Z35 4Z36	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?