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GNAI3 and CXCR2
Number of citations of the paper that reports this interaction (PubMedID
8316840
)
72
Data Source:
HPRD
(in vivo)
GNAI3
CXCR2
Description
G protein subunit alpha i3
C-X-C motif chemokine receptor 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Centrosome
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Midbody
Zymogen Granule
Membrane Raft
Extracellular Exosome
Nucleoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Microtubule Cytoskeleton
Membrane
Secretory Granule Membrane
Mast Cell Granule
Mitotic Spindle
Molecular Function
G Protein-coupled Receptor Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Domain Specific Binding
G-protein Beta/gamma-subunit Complex Binding
G Protein-coupled Serotonin Receptor Binding
GTPase Activating Protein Binding
Metal Ion Binding
Interleukin-8 Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-X-C Chemokine Receptor Activity
C-C Chemokine Binding
Interleukin-8 Binding
Biological Process
Vesicle Fusion
Cell Cycle
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Dopamine Receptor Signaling Pathway
Brain Development
Positive Regulation Of Macroautophagy
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of NAD(P)H Oxidase Activity
GTP Metabolic Process
Cell Division
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Apoptotic Signaling Pathway
Dendritic Cell Chemotaxis
Acute Inflammatory Response To Antigenic Stimulus
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Calcium-mediated Signaling
Neutrophil Chemotaxis
Midbrain Development
Receptor Internalization
Negative Regulation Of Neutrophil Apoptotic Process
Interleukin-8-mediated Signaling Pathway
Neutrophil Activation
Positive Regulation Of Vascular Permeability
Positive Regulation Of Angiogenesis
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Metanephric Tubule Morphogenesis
Positive Regulation Of Neutrophil Chemotaxis
Pathways
Adenylate cyclase inhibitory pathway
Adenylate cyclase inhibitory pathway
ADP signalling through P2Y purinoceptor 12
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation
Drugs
Diseases
GWAS
Childhood body mass index (
33045005
)
Major depressive disorder (
20125088
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Granulocyte count (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
28067908
23128233
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Smooth-surface caries (
23470693
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
32888494
27863252
)
Interacting Genes
43 interacting genes:
AGTR2
ATP12A
CCDC88A
CCDC88C
CCR5
CD48
CD59
CNR1
CXCR2
DRD2
GNB2
GNB4
GPSM1
GPSM2
GPSM3
HTR1A
LPAR1
MTNR1A
MTNR1B
NGB
NUCB1
NUCB2
PCP2
PHF24
PRKAR2B
PTPRU
RANGAP1
RGS10
RGS12
RGS14
RGS16
RGS17
RGS18
RGS19
RGS2
RGS20
RGS3
RGS5
RGS7
RIC8A
S1PR1
SOX30
TSHR
32 interacting genes:
ADRA1A
ARRB1
ATP13A1
C4orf3
CLDN22
CXCL1
CXCL2
CXCL3
CXCL5
CXCL6
CXCL8
CXCR1
EMP1
FKBP8
GNA14
GNA15
GNAI2
GNAI3
GPRASP1
GRIA1
MYO5B
PPBP
PPP2CA
RAB11FIP2
RGS12
SLC18A2
SLC39A2
SMCO4
ST13
TMEM147
TMEM80
TRARG1
Entrez ID
2773
3579
HPRD ID
00765
00907
Ensembl ID
ENSG00000065135
ENSG00000180871
Uniprot IDs
P08754
P25025
Q53PC4
PDB IDs
2IHB
2ODE
2V4Z
4G5O
4G5R
4G5S
4Q3H
5TYT
6KVA
6KVF
6LFM
6LFO
Enriched GO Terms of Interacting Partners
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