DPAGT1 and LSM8

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		DPAGT1	LSM8
Description		dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	LSM8 homolog, U6 small nuclear RNA associated
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex
	Molecular Function	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Phospho-N-acetylmuramoyl-pentapeptide-transferase Activity Glycosyltransferase Activity Identical Protein Binding Metal Ion Binding	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	UDP-N-acetylglucosamine Metabolic Process Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Dolichol Metabolic Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 33627673 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)
Interacting Genes		7 interacting genes: CXCR5 ETS1 LSM8 MFSD3 THTPA TUBE1 WDR5	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		1798	51691
HPRD ID		01879	06288
Ensembl ID		ENSG00000172269	ENSG00000128534
Uniprot IDs		A0A024R3H8 Q9H3H5	A4D0W0 O95777
PDB IDs		5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG
Enriched GO Terms of Interacting Partners?
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