DNM2 and CCR5

Number of citations of the paper that reports this interaction (PubMedID 10477567)
20

Data Source:
HPRD (in vivo)

		DNM2	CCR5
Description		dynamin 2	C-C motif chemokine receptor 5
Image
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Lamellipodium Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Ruffle Membrane Protein-containing Complex Synapse Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding D2 Dopamine Receptor Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Protein-containing Complex Binding WW Domain Binding Nitric-oxide Synthase Binding	Virus Receptor Activity Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle G Protein-coupled Receptor Internalization Regulation Of Transcription, DNA-templated Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Signal Transduction Spermatogenesis Response To Light Stimulus Positive Regulation Of Lamellipodium Assembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Receptor Internalization Transferrin Transport Regulation Of Rac Protein Signal Transduction Response To Cocaine Positive Regulation Of Apoptotic Process Macropinocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Neuron Projection Morphogenesis Positive Regulation Of Phagocytosis Membrane Organization Cellular Response To Carbon Monoxide Cellular Response To X-ray Cellular Response To Nitric Oxide Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Non-motile Cilium Assembly Cellular Response To Dopamine Regulation Of Golgi Organization Positive Regulation Of P-type Sodium:potassium-exchanging Transporter Activity Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Viral Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription	Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)	Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		79 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 COG6 CTTN DDX39B DNAJB1 DNM1 DNMT1 DYNC1I1 DYNLL1 EIF3L ELAVL1 EPS15 FLAD1 FNBP1L FXR1 FXR2 GCDH GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NDC1 NTAQ1 PALS2 PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6	43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK
Entrez ID		1785	1234
HPRD ID		03852	03223
Ensembl ID		ENSG00000079805	ENSG00000160791
Uniprot IDs		P50570 Q8N1K8	P51681 Q38L21
PDB IDs		2YS1	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET
Enriched GO Terms of Interacting Partners?
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