DLAT and PDHA1

Number of citations of the paper that reports this interaction (PubMedID 14638692)
40

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		DLAT	PDHA1
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase E1 subunit alpha 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Tricarboxylic Acid Cycle Sleep	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		NADH Radicicol Dihydrolipoic Acid	NADH
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: HMGB1 PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	8 interacting genes: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		1737	5160
HPRD ID		10578	02420
Ensembl ID		ENSG00000150768	ENSG00000131828
Uniprot IDs		P10515 Q86YI5	A0A024RBX9 P08559
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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