DLAT and PRKD3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DLAT	PRKD3
Description		dihydrolipoamide S-acetyltransferase	protein kinase D3
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex	Nucleoplasm Cytosol Membrane
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding	Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Tricarboxylic Acid Cycle Sleep	Protein Phosphorylation Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Protein Kinase D Signaling
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Sphingolipid de novo biosynthesis
Drugs		NADH Radicicol Dihydrolipoic Acid
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease ( 34099642) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 28165464 24292274) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Pulse pressure ( 27841878) Schizophrenia ( 33169155 23974872) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		8 interacting genes: HMGB1 PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	13 interacting genes: BCL6 DLAT DYNLL2 GSK3A IKBKG KPNA2 KPNB1 MYH3 NUDT3 POLL SKA2 TAF1 VAMP2
Entrez ID		1737	23683
HPRD ID		10578	06151
Ensembl ID		ENSG00000150768	ENSG00000115825
Uniprot IDs		P10515 Q86YI5	O94806
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55	2D9Z
Enriched GO Terms of Interacting Partners?
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