DCP2 and DCP1B

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		DCP2	DCP1B
Description		decapping mRNA 2	decapping mRNA 1B
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	5'-3' Exoribonuclease Activity Protein Binding Exoribonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding M7G(5')pppN Diphosphatase Activity Telomerase RNA Binding	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Telomerase RNA Localization To Cajal Body	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Waist circumference ( 32902719) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Grapefruit juice consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)
Interacting Genes		20 interacting genes: ACKR2 AGO1 AGO2 CYP27A1 DCP1A DCP1B EPB41L4A FEM1C KCNN2 MAPK3 MIR15B MTOR MX1 NAGK POLA2 PSMB1 TMED7 TRIM21 UPF1 UPF2	11 interacting genes: DCP2 EXOSC6 GSK3A GSK3B LSM8 MIR15B NSMAF SMAD4 UPF2 XRN1 ZFP36
Entrez ID		167227	196513
HPRD ID		13125	13124
Ensembl ID		ENSG00000172795	ENSG00000151065
Uniprot IDs		Q8IU60	B4DVJ6 Q8IZD4
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?