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NOD2 and TNIP1
Number of citations of the paper that reports this interaction (PubMedID
27812135
)
4
Data Source:
BioGRID
(two hybrid)
NOD2
TNIP1
Description
nucleotide binding oligomerization domain containing 2
TNFAIP3 interacting protein 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Vesicle
Protein-containing Complex
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Nucleoplasm
Cytosol
Molecular Function
Actin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Hsp70 Protein Binding
Muramyl Dipeptide Binding
Pattern Recognition Receptor Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Hsp90 Protein Binding
Protein Binding
Identical Protein Binding
Mitogen-activated Protein Kinase Binding
Biological Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response In Mucosa
Activation Of Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Intracellular Signal Transduction
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Translation
Defense Response
Inflammatory Response
Leukocyte Cell-cell Adhesion
Glycoprotein Biosynthetic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade
Positive Regulation Of Protein Deubiquitination
Pathways
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Ovarian tumor domain proteases
Drugs
Mifamurtide
Diseases
GWAS
Asthma (
31361310
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
28067908
)
Leprosy (
20018961
27976721
25642632
)
Medication use (thyroid preparations) (
31015401
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Amyotrophic lateral sclerosis (
29566793
)
Autoimmune traits (pleiotropy) (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Cutaneous psoriasis (
26626624
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Inflammatory bowel disease (
28067908
23128233
)
Inflammatory skin disease (
25574825
)
LDL cholesterol levels in HIV infection (
33109212
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Myasthenia gravis (
23055271
)
Neutrophil percentage of granulocytes (
27863252
)
Psoriasis (
25854761
25903422
25574825
23143594
19169254
)
Psoriasis vulgaris (
26626624
29031612
)
Psoriatic arthritis (
26626624
)
Rheumatoid arthritis (
30572963
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Serum alkaline phosphatase levels (
33547301
)
Sjögren's syndrome (
24097067
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
26606652
23273568
33272962
26502338
28714469
19838193
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic sclerosis (
21750679
31672989
30572963
29293537
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Interacting Genes
40 interacting genes:
ALPI
ANKHD1
ANXA2
ATG16L1
C10orf67
CCL13
CHMP4B
CHMP5
CNOT1
DCTN1
DOCK7
ENTR1
ERBIN
GOLGA6L5P
GOLGB1
HAP1
IKBIP
IRGM
LDOC1
LMNA
LURAP1L
MAP3K7
NLRC4
PDLIM5
PPP1R12C
PPP2R3B
PRR16
RIPK2
RPL13A
SCYL1
SETD6
TACC3
TNIP1
TPM1
TPM3
TPM4
TRIM41
VCP
WBP11
XIAP
95 interacting genes:
ABHD17A
ADH6
AP1M1
BYSL
C8orf33
CCDC112
CCDC121
CCNG1
CDC23
CDC37
CDIP1
CDKN1A
CFAP53
CYSRT1
DAZAP2
DPPA4
EFEMP1
EHHADH
ELOA
FAM161A
FAM168A
FUS
FXR1
GABARAPL1
GABARAPL2
GIT2
GTF2B
GTF2H1
HDAC1
HDDC3
IKBKG
KIFC3
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
LENG8
LITAF
MAGEB18
MAGEH1
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K1
MAPK1
MAPK10
MCM10
MCRS1
MOB1B
MOB3C
MORF4L1
MORF4L2
NFKB1
NIFK
NME7
NOD2
OPTN
PIBF1
PIN1
PNKP
RABAC1
RALBP1
RARA
RARG
RBFOX1
RNF11
RNF8
RPL5
S100B
SELPLG
SHTN1
SNIP1
SPATA2
SUMO2
SYT6
TAX1BP1
TCEA2
TCEANC
TCEANC2
TNFAIP3
TNIP3
TSG101
TTC39A
TTF2
TXLNA
TYRO3
UBC
VPS33B
WTAP
ZBTB25
ZMAT2
ZNHIT1
Entrez ID
64127
10318
HPRD ID
05810
09216
Ensembl ID
ENSG00000167207
ENSG00000145901
Uniprot IDs
A0A286YF65
Q9HC29
A0A0A0MRZ4
A8K4N4
B7Z8K2
Q15025
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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