AP2A1 and SYNJ1

Number of citations of the paper that reports this interaction (PubMedID 12057195)
71

Data Source:
BioGRID (pull down)

		AP2A1	SYNJ1
Description		adaptor related protein complex 2 subunit alpha 1	synaptojanin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Endolysosome Membrane Clathrin-coated Endocytic Vesicle	Cytosol Microtubule Vesicle Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Parallel Fiber To Purkinje Cell Synapse Presynapse
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding Cargo Adaptor Activity	RNA Binding Phosphatidylinositol-3-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein C-terminus Binding SH3 Domain Binding Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Protein-containing Complex Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity EH Domain Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Neuron Projection Development Positive Regulation Of Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Brain Development Learning Positive Regulation Of Gliogenesis Synaptic Vesicle Priming Synaptic Vesicle Uncoating Response To Retinoic Acid Response To Cytokine Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		28 interacting genes: AAGAB AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	25 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2 VPS26C
Entrez ID		160	8867
HPRD ID		03016	09182
Ensembl ID		ENSG00000196961	ENSG00000159082
Uniprot IDs		O95782	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs			1W80 2DNR 2VJ0 7A0V
Enriched GO Terms of Interacting Partners?
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