AP2A1 and EPN1

Number of citations of the paper that reports this interaction (PubMedID 9723620)
179

Data Source:
HPRD (in vivo, in vitro)

		AP2A1	EPN1
Description		adaptor related protein complex 2 subunit alpha 1	epsin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Endolysosome Membrane Clathrin-coated Endocytic Vesicle	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding Cargo Adaptor Activity	Protein Binding Phospholipid Binding Clathrin Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Neuron Projection Development Positive Regulation Of Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Embryonic Organ Development Negative Regulation Of Sprouting Angiogenesis
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS			Major depressive disorder ( 23377640)
Interacting Genes		28 interacting genes: AAGAB AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16
Entrez ID		160	29924
HPRD ID		03016	06270
Ensembl ID		ENSG00000196961	ENSG00000063245
Uniprot IDs		O95782	A0A024R4S1 Q9Y6I3
PDB IDs			1INZ 1KYD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?