RHOXF1 and NPAS2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		RHOXF1	NPAS2
Description		Rhox homeobox family member 1	neuronal PAS domain protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol CLOCK-BMAL Transcription Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Gamete Generation Positive Regulation Of Gene Expression Sexual Reproduction Intracellular Steroid Hormone Receptor Signaling Pathway Enteric Nervous System Development	Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Central Nervous System Development Response To Xenobiotic Stimulus Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Redox State Negative Regulation Of Cell Death Positive Regulation Of Behavioral Fear Response Regulation Of Response To DNA Damage Stimulus
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression Circadian Clock Heme signaling
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31798171 31959993 30054594) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: MAP1LC3C NPAS2 VTN	30 interacting genes: ARNT2 ARNTL ARNTL2 BPIFA1 CLOCK CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1
Entrez ID		158800	4862
HPRD ID		15954	09137
Ensembl ID		ENSG00000101883	ENSG00000170485
Uniprot IDs		Q8NHV9	A2I2P5 Q99743
PDB IDs
Enriched GO Terms of Interacting Partners?
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