NPAS2 and HESX1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		NPAS2	HESX1
Description		neuronal PAS domain protein 2	HESX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol CLOCK-BMAL Transcription Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Protein N-terminus Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Central Nervous System Development Response To Xenobiotic Stimulus Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Redox State Negative Regulation Of Cell Death Positive Regulation Of Behavioral Fear Response Regulation Of Response To DNA Damage Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Brain Development Gonad Development Gene Expression Stem Cell Population Maintenance Pituitary Gland Development Thyroid Gland Development Otic Vesicle Formation Multicellular Organism Growth Camera-type Eye Development Nose Development Regulation Of Embryonic Development Forebrain Morphogenesis Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Canonical Wnt Signaling Pathway ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression Circadian Clock Heme signaling
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31798171 31959993 30054594) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		30 interacting genes: ARNT2 ARNTL ARNTL2 BPIFA1 CLOCK CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1	12 interacting genes: C1orf109 CATIP GUCD1 HOXC8 KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1 UBL5
Entrez ID		4862	8820
HPRD ID		09137	03482
Ensembl ID		ENSG00000170485	ENSG00000163666
Uniprot IDs		A2I2P5 Q99743	A1LQR0 Q9UBX0
PDB IDs			2K40
Enriched GO Terms of Interacting Partners?
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