CYP2D6 and CYB5A

Number of citations of the paper that reports this interaction (PubMedID 15680923)
23

Data Source:
BioGRID (pull down)

		CYP2D6	CYB5A
Description		cytochrome P450 family 2 subfamily D member 6	cytochrome b5 type A
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity	Cytochrome-c Oxidase Activity Protein Binding Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process	Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport
Pathways		Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs	Vitamin C (ascorbate) metabolism
Drugs		Cannabidiol Diacerein Nabiximols	Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Intelligence ( 28530673) Refractive error ( 32231278) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Schizophrenia ( 25056061 29483656) Urinary metabolite levels in chronic kidney disease ( 31959995)	Blood protein levels ( 30072576)
Interacting Genes		3 interacting genes: CYB5A CYP2C9 POR	14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4
Entrez ID		1565	1528
HPRD ID		00487	08941
Ensembl ID		ENSG00000100197	ENSG00000166347
Uniprot IDs		C1ID52 P10635 Q5Y7H2	A0A384ME44 P00167
PDB IDs		2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU 6CSB 6CSD	2I96
Enriched GO Terms of Interacting Partners?
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