CYB5A and CYP2D6

Number of citations of the paper that reports this interaction (PubMedID 15680923)
23

Data Source:
BioGRID (pull down)

		CYB5A	CYP2D6
Description		cytochrome b5 type A	cytochrome P450 family 2 subfamily D member 6
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Enzyme Binding Heme Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity
	Biological Process	Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process
Pathways		Vitamin C (ascorbate) metabolism	Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Blood protein levels ( 30072576)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Intelligence ( 28530673) Refractive error ( 32231278) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Schizophrenia ( 25056061 29483656) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	3 interacting genes: CYB5A CYP2C9 POR
Entrez ID		1528	1565
HPRD ID		08941	00487
Ensembl ID		ENSG00000166347	ENSG00000100197
Uniprot IDs		A0A384ME44 P00167	C1ID52 P10635 Q5Y7H2
PDB IDs		2I96	2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU 6CSB 6CSD
Enriched GO Terms of Interacting Partners?
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