ADRB1 and GPRASP2

Number of citations of the paper that reports this interaction (PubMedID 15086532)
40

Data Source:
HPRD (in vitro)

		ADRB1	GPRASP2
Description		adrenoceptor beta 1	G protein-coupled receptor associated sorting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse	Nucleus Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Activation Of Adenylate Cyclase Activity Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Fear Response Positive Regulation Of GTPase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Brown Fat Cell Differentiation Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Hematopoietic Stem Cell Homeostasis
Pathways		Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Spermine Amphetamine Esmolol Betaxolol Bethanidine Isoetharine Ranolazine Cabergoline Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Loxapine Sotalol Carteolol Nortriptyline Lamotrigine Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Dobutamine Pseudoephedrine Alprenolol Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Clenbuterol Oxprenolol Putrescine Spermidine Celiprolol Dronedarone Nebivolol Asenapine Droxidopa Bufuralol 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol Befunolol Vortioxetine Arotinolol Levobetaxolol Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Dihydroergocristine Xamoterol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 23202124 31043758 27680694) Blood pressure ( 21909110) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gaucher disease severity ( 22388998) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Platelet distribution width ( 32888494) PR interval ( 32439900) Systolic blood pressure ( 27841878 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		16 interacting genes: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 RTL10 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688
Entrez ID		153	114928
HPRD ID		00181	06612
Ensembl ID		ENSG00000043591	ENSG00000158301
Uniprot IDs		P08588	B3KW05 Q96D09
PDB IDs		2LSQ
Enriched GO Terms of Interacting Partners?
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