CTSZ and TNS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CTSZ	TNS2
Description		cathepsin Z	tensin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Growth Cone Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Cell Cortex Region Ficolin-1-rich Granule Lumen	Plasma Membrane Focal Adhesion
	Molecular Function	Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Angiotensin Maturation Proteolysis Negative Regulation Of Plasminogen Activation Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Binding Positive Regulation Of Neuron Apoptotic Process Proteolysis Involved In Cellular Protein Catabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Neural Precursor Cell Proliferation	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal Homeostasis
Pathways		Metabolism of Angiotensinogen to Angiotensins COPII-mediated vesicle transport Lysosome Vesicle Biogenesis Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Hematocrit ( 32888494) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Mean platelet volume ( 22139419 24026423 32888494 27863252) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		21 interacting genes: BACH2 BANP CYSRT1 FHL5 HSF2BP KRT35 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-10 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP6-3 MID2 MTUS2 NBPF19 NOTCH2NLA PLSCR1 TNS2	150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837
Entrez ID		1522	23371
HPRD ID		04410	16256
Ensembl ID		ENSG00000101160	ENSG00000111077
Uniprot IDs		Q9UBR2	A0A024RB48 Q63HR2
PDB IDs		1DEU 1EF7	2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?
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