TNS2 and GBA3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		TNS2	GBA3
Description		tensin 2	glucosylceramidase beta 3 (gene/pseudogene)
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Cytosol Catalytic Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding	Galactosylceramidase Activity Glucosylceramidase Activity Beta-galactosidase Activity Protein Binding Beta-glucosidase Activity Glycosylceramidase Activity Scopolin Beta-glucosidase Activity
	Biological Process	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal Homeostasis	Glucosylceramide Catabolic Process Galactosylceramide Catabolic Process Glycosphingolipid Metabolic Process Glycoside Catabolic Process Glycosylceramide Catabolic Process Protein Stabilization Cellular Oligosaccharide Catabolic Process Beta-glucoside Catabolic Process Positive Regulation Of Exo-alpha-sialidase Activity
Pathways			Glycosphingolipid metabolism
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 30946743) Anti-saccade response ( 29064472) Blood metabolite levels ( 24816252) Fasting glucose ( 33381925) Manganese levels ( 26025379) Metabolite levels ( 23823483) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Rosacea symptom severity ( 29771307) Serum metabolite levels ( 33031748 23093944) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837	2 interacting genes: PRKCSH TNS2
Entrez ID		23371	57733
HPRD ID		16256	09428
Ensembl ID		ENSG00000111077	ENSG00000249948
Uniprot IDs		A0A024RB48 Q63HR2	A8K9N1 B7Z536 Q9H227
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	2E9L 2E9M 2JFE 2ZOX 3VKK
Enriched GO Terms of Interacting Partners?
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