COMMD1 and CUL4A

Number of citations of the paper that reports this interaction (PubMedID 21778237)
12

Data Source:
BioGRID (pull down)

		COMMD1	CUL4A
Description		copper metabolism domain containing 1	cullin 4A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Nucleoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Somatic Stem Cell Population Maintenance Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair
Pathways		Neddylation	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494 27863252) Red cell distribution width ( 32888494)
Interacting Genes		34 interacting genes: BAHCC1 BARD1 BRCA1 C2orf74 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC HMGB2 KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT WDPCP XIAP	25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS5 CUL4B DCAF6 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 IRS2 RBX1 RNF7 SALL2 SENP8 SKP2 ST7 TUBG1 UBC UBE2E3 UBE2M
Entrez ID		150684	8451
HPRD ID		06253	07218
Ensembl ID		ENSG00000173163	ENSG00000139842
Uniprot IDs		Q8N668	A0A0A0MR50 Q13619
PDB IDs		2H2M	2HYE 4A0K
Enriched GO Terms of Interacting Partners?
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