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CTNNB1 and SMAD4
Number of citations of the paper that reports this interaction (PubMedID
12000714
)
33
Data Source:
HPRD
(in vivo)
CTNNB1
SMAD4
Description
catenin beta 1
SMAD family member 4
Image
GO Annotations
Cellular Component
Euchromatin
Spindle Pole
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Fascia Adherens
Bicellular Tight Junction
Focal Adhesion
Cell Cortex
Membrane
Basolateral Plasma Membrane
Apicolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Flotillin Complex
Z Disc
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Microvillus Membrane
Protein-containing Complex
Protein-DNA Complex
Scrib-APC-beta-catenin Complex
Presynaptic Membrane
Apical Part Of Cell
Synapse
Postsynaptic Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Beta-catenin-TCF7L2 Complex
Cell Periphery
Schaffer Collateral - CA1 Synapse
Presynaptic Active Zone Cytoplasmic Component
Postsynaptic Density, Intracellular Component
Beta-catenin-TCF Complex
Wnt Signalosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
Transcription Coregulator Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Nuclear Receptor Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Transmembrane Transporter Binding
Alpha-catenin Binding
Cadherin Binding
SMAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Histone Methyltransferase Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
R-SMAD Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Embryonic Axis Specification
Cell Morphogenesis Involved In Differentiation
Branching Involved In Blood Vessel Morphogenesis
Branching Involved In Ureteric Bud Morphogenesis
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Cell Fate Specification
Endodermal Cell Fate Commitment
Neuron Migration
Epithelial To Mesenchymal Transition
Neural Plate Development
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Morphogenesis In Camera-type Eye
Regulation Of Secondary Heart Field Cardioblast Proliferation
Metanephros Morphogenesis
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Cell Adhesion
Cell-matrix Adhesion
Chemical Synaptic Transmission
Ectoderm Development
Glial Cell Fate Determination
Negative Regulation Of Cell Population Proliferation
Anterior/posterior Axis Specification
Dorsal/ventral Axis Specification
Proximal/distal Pattern Formation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Layer Formation In Cerebral Cortex
Central Nervous System Vasculogenesis
Osteoclast Differentiation
Male Genitalia Development
Hindbrain Development
Regulation Of Centriole-centriole Cohesion
Pancreas Development
Hair Follicle Morphogenesis
Regulation Of Myelination
Positive Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Chondrocyte Differentiation
Response To Estradiol
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
T Cell Differentiation In Thymus
Negative Regulation Of Protein Sumoylation
Adherens Junction Assembly
Protein Localization To Cell Surface
Embryonic Heart Tube Development
Genitalia Morphogenesis
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Hair Cell Differentiation
Detection Of Muscle Stretch
Embryonic Skeletal Limb Joint Morphogenesis
Astrocyte-dopaminergic Neuron Signaling
Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation
Bone Resorption
Positive Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Regulation Of Fibroblast Proliferation
Cell Maturation
Synaptic Vesicle Transport
Thymus Development
Oocyte Development
Embryonic Foregut Morphogenesis
Positive Regulation Of Skeletal Muscle Tissue Development
Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Oligodendrocyte Differentiation
Regulation Of Neurogenesis
Synapse Organization
Positive Regulation Of DNA-binding Transcription Factor Activity
Smooth Muscle Cell Differentiation
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Timing Of Anagen
Positive Regulation Of Telomerase Activity
Oviduct Development
Canonical Wnt Signaling Pathway
Trachea Formation
Epithelial Tube Branching Involved In Lung Morphogenesis
Lung Cell Differentiation
Lung-associated Mesenchyme Development
Lung Induction
Epithelial Cell Differentiation Involved In Prostate Gland Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Hair Follicle Placode Formation
Mesenchymal Cell Proliferation Involved In Lung Development
Positive Regulation Of Branching Involved In Lung Morphogenesis
Endothelial Tube Morphogenesis
Fungiform Papilla Formation
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Sympathetic Ganglion Development
Cranial Ganglion Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Growth Factor Stimulus
Cellular Response To Indole-3-methanol
Renal Vesicle Formation
Renal Inner Medulla Development
Renal Outer Medulla Development
Nephron Tubule Formation
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Regulation Of Calcium Ion Import
Synaptic Vesicle Clustering
Cell-cell Adhesion
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Core Promoter Binding
Cranial Skeletal System Development
Midbrain Dopaminergic Neuron Differentiation
Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Neuron Projection Extension
Embryonic Brain Development
Dorsal Root Ganglion Development
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Determination Of Dorsal Identity
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Brainstem Development
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Spermatogenesis
Single Fertilization
Axon Guidance
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Differentiation
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Differentiation
Negative Regulation Of Cell Growth
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Luteinizing Hormone Secretion
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Embryonic Digit Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Binding
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Histone H3-K9 Acetylation
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Apoptotic cleavage of cell adhesion proteins
Deactivation of the beta-catenin transactivating complex
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Ca2+ pathway
Adherens junctions interactions
Binding of TCF/LEF:CTNNB1 to target gene promoters
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
Myogenesis
Myogenesis
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
RHO GTPases activate IQGAPs
Transcriptional Regulation by VENTX
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX3 regulates WNT signaling
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Drugs
Urea
Diseases
GWAS
Bone mineral density (hip) (
27311723
19801982
)
Bone mineral density (total hip) (
29883787
)
Colorectal cancer (
26151821
)
Colorectal cancer or advanced adenoma (
30510241
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
High myopia (
31816047
)
Lumbar spine bone mineral density (
29499414
)
Refractive error (
32231278
)
Systolic blood pressure (
30224653
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Interacting Genes
198 interacting genes:
ACP1
AJAP1
AKT1
AMER1
APC
APC2
APP
AR
ARFGEF1
ARHGAP32
ARHGEF4
ASGR2
ASH2L
AXIN1
AXIN2
BCL3
BCL6
BCL9
BCL9L
BOC
BRCA1
BTRC
CA9
CARM1
CASP3
CASP8
CBL
CBY1
CCND1
CCR1
CDC25A
CDC27
CDC73
CDH1
CDH11
CDH15
CDH16
CDH2
CDH24
CDH3
CDH5
CDH7
CDH8
CDH9
CDK1
CDK2
CDK5
CDK5R1
CDK6
CDON
CEBPA
CHD8
CHUK
CREBBP
CSNK1A1
CSNK1D
CSNK2A1
CSNK2B
CTNNA1
CTNNA3
CTNNBIP1
CTNND2
DLG5
DSC3
DVL1
DVL3
EGFR
ELAVL1
EP300
ERBB2
ERBIN
ESR1
EZR
FBXW2
FER
FHIT
FHL2
FLT1
FOXO1
FOXO4
FSCN1
FUS
FYN
GLIS2
GLUD1
GNA13
GNAI2
GRIK2
GRIN1
GRIN2D
GSK3B
H1-2
HIF1A
HNF1A
HUWE1
IGF2BP1
IKBKB
IQGAP1
JADE1
KAT2A
KAT2B
KDR
KMT2A
KMT2D
LAMB2
LATS2
LEF1
LEO1
MAGI1
MAGI2
MAP3K2
MAPK8
MAPK9
MEN1
MET
MITF
MUC1
NCOA2
NDRG1
NEK2
NEURL2
NF2
NFKB1
NOTCH1
NR5A1
PECAM1
PICK1
PIK3R1
PIN1
PITX2
PKD1
PKM
PKP2
PLK1
PPM1A
PRKCG
PSEN1
PSEN2
PTGS2
PTPN1
PTPN13
PTPN14
PTPN6
PTPRB
PTPRF
PTPRJ
PTPRK
PTPRM
PTPRU
PTPRZ1
PYGO1
RAPGEF2
RBBP5
RUVBL1
RUVBL2
RXRA
SALL1
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCA4
SMARCA5
SMURF1
SOX1
SOX17
SP1
SPN
SRC
SSTR3
STUB1
TAX1BP3
TBL1X
TCF3
TCF4
TCF7L1
TCF7L2
TFAP2A
TGFBR1
TGFBR2
TJP1
TLE1
TRIM33
TRIM55
TRIM63
TRIP10
TRRAP
TSC1
UBE2B
UBE2D1
UBE2R2
UBE2S
UBE3A
UHRF2
USP9X
ZFYVE9
ZIC3
214 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFIA
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RELA
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TIAF1
TLE5
TM9SF2
TOB1
TRAP1
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
Entrez ID
1499
4089
HPRD ID
00286
02995
Ensembl ID
ENSG00000168036
ENSG00000141646
Uniprot IDs
A0A024R2Q3
B4DGU4
P35222
A0A024R274
Q13485
PDB IDs
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
4DJS
6M90
6M91
6M92
6M93
6M94
6O9B
6O9C
6WLX
6WNX
7AFW
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
Enriched GO Terms of Interacting Partners
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