CTH and RECK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		CTH	RECK
Description		cystathionine gamma-lyase	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Declining hemoglobin trajectory in blood donors ( 33491795) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Seasonality and depression ( 30217971)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		5 interacting genes: GUCD1 NTAQ1 PTGFR RECK SDCBP2	44 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL RPS6KA1 SIGMAR1 SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		1491	8434
HPRD ID		09633	05567
Ensembl ID		ENSG00000116761	ENSG00000122707
Uniprot IDs		P32929	A8K9D8 O95980 Q6P9E2
PDB IDs		2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA 6OVG
Enriched GO Terms of Interacting Partners?
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