CSTF1 and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (pull down)

		CSTF1	TOLLIP
Description		cleavage stimulation factor subunit 1	toll interacting protein
Image
GO Annotations	Cellular Component	Nucleoplasm MRNA Cleavage Stimulating Factor Complex	Extracellular Region Cytoplasm Cytosol Nuclear Body Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding
	Biological Process	MRNA 3'-end Processing	Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways		mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Cognitive decline (age-related) ( 28078323)	Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		12 interacting genes: BARD1 BRCA1 CSTF3 H2AC20 MIR140 MIR206 MIR92A2 MIRLET7A3 MIRLET7I POLR2A TOLLIP VCP	78 interacting genes: ACTN2 ARRDC3 ATXN1 BHLHE40 C19orf54 CDIP1 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 EIF2AK2 FAM166B FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TOM1L2 TTC9C UBC USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19 ZRANB1
Entrez ID		1477	54472
HPRD ID		02653	05887
Ensembl ID		ENSG00000101138	ENSG00000078902
Uniprot IDs		Q05048	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		6B3X	1WGL 2N31
Enriched GO Terms of Interacting Partners?
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